Immune System

Autoimmune Flare Support

Calm an overactive immune system during flares of Hashimoto's, RA, lupus, psoriasis, IBD, and related conditions — lower systemic inflammation, support the gut barrier, and modulate (not stimulate) immunity.

Prevention

Key nutrients: Vitamin D, omega-3 (EPA/DHA), curcumin, zinc, selenium, glutamine, polyphenols.

Eat regularly: Wild salmon, sardines, brazil nuts, bone broth, fermented vegetables, leafy greens, berries, turmeric, ginger, extra-virgin olive oil.

Identify and remove common triggers (gluten, dairy, alcohol, ultra-processed foods, poor sleep, chronic stress). Avoid immune stimulants like echinacea and astragalus during active flares.

High-dose vitamin D3

VitaminStrong evidence

5,000–10,000 IU daily with K2 — most autoimmune patients run deficient; restoring levels to 60–80 ng/ml is a foundational step.

⚠ Cautions: Test blood levels every 3 months at higher doses.

Omega-3 (EPA/DHA)

OtherStrong evidence

2–4 g combined EPA+DHA daily — one of the most consistent anti-inflammatory interventions across autoimmune conditions.

Curcumin (turmeric extract)

HerbStrong evidence

500–1000 mg liposomal or Meriva curcumin 2× daily with food to lower systemic inflammation during a flare.

⚠ Cautions: May potentiate blood thinners.

Low-dose naltrexone (LDN)

OtherModerate evidence

1.5–4.5 mg at bedtime — prescription-only; growing evidence in Hashimoto's, MS, Crohn's, lupus, and fibromyalgia for immune modulation.

⚠ Cautions: Requires a prescribing practitioner familiar with LDN.

Reishi mushroom

HerbModerate evidence

1–3 g dual-extract daily — an immune modulator (not stimulator), gently calming overactive Th17 pathways.

Pairs well with: Cordyceps for fatigue

L-glutamine

OtherModerate evidence

5 g powder in water 1–2× daily supports the intestinal barrier — leaky gut is a recognized driver of autoimmune flares.

Boswellia serrata

HerbStrong evidence

300–400 mg standardized extract 3× daily — eases joint, gut, and skin inflammation without irritating the stomach.

A note of caution. Natural doesn't mean risk-free. Herbs and supplements can interact with medications, affect pregnancy, or worsen certain conditions. Speak with a qualified clinician before starting a new regimen, especially if you take prescriptions.