Seasonal Affective Disorder (SAD)
Lift winter depression, low energy, carb cravings, and oversleeping with high-dose vitamin D, St. John's wort, saffron, and circadian-rhythm support — natural alternatives to (or alongside) light therapy.
Vitamin D3 (high dose, Oct–Mar)
VitaminStrong evidence5000–10000 IU/day in winter months (with K2) to maintain serum 25(OH)D of 60–80 ng/mL — winter deficiency is the single biggest driver of SAD in northern latitudes.
St. John's wort
HerbStrong evidence300 mg standardized extract (0.3% hypericin) 3×/day for 6–12 weeks — clinically comparable to SSRIs for mild–moderate seasonal depression.
Saffron
HerbStrong evidence30 mg standardized extract daily — randomized trials show antidepressant effect comparable to fluoxetine, with fewer side effects.
5-HTP
OtherModerate evidence100–200 mg 1–2×/day (start at bedtime) — supports serotonin synthesis when daylight is scarce.
Omega-3 (high EPA)
OtherStrong evidence2 g EPA/day — clinical evidence for improved mood and energy, especially when vitamin D is also corrected.
Rhodiola rosea
HerbModerate evidence200–400 mg standardized extract in the morning — adaptogen that fights winter fatigue, low motivation, and brain fog.
Light therapy (10,000 lux)
OtherStrong evidence20–30 min within an hour of waking, 16 inches from a 10,000-lux light box — the most evidence-based non-pharmacologic treatment for SAD.
B-complex with methylfolate
VitaminStrong evidenceFull activated B-complex with 400–800 mcg methylfolate and 1000 mcg methyl B12 daily — supports neurotransmitter synthesis and energy in winter.